Home
About Us
Search
Site Map
Contact Us
Research Ethics Program
Courses
Seminar Series
Resources
What's New?
Biomedical Ethics Seminar Series
 Back to Calendar 2007

Wednesday, January 17, 2007

Topic: Research MR Exams in Liver Transplant Patients: Ethical and Clinical Issues
Presenter: Claude Sirlin, M.D., Dept. of Radiology, UCSD
Location: Medical Teaching Facility (MTF) 175
Presentation
Abstract:
Dr. Sirlin is an assistant professor of radiology at UCSD, Chief of Body MRI, and Director of the Liver Imaging Research Group. His group focuses on developing new techniques for liver imaging.

Dr. Sirlin is planning a prospective clinical study to determine the accuracy of MR imaging for hepatocellular  carcinoma (HCC) in cirrhotic patients on the liver transplant waiting  list. The proposed study will recruit liver transplant patients. Enrolled subjects will undergo a liver MR exam for research purposes immediately before liver transplantation. (MR imaging to detect liver cancer is not routinely performed immediately before transplantation.)

From a purely scientific point of view, it would be ideal not to divulge to the research subject, hepatologist, or surgeon any information discovered at MR until after the transplant. However, the release of some information prior to transplant may be beneficial to the patient, e.g., by helping to guide the surgical approach. Alternatively, if the patient is not a suitable candidate for transplant (due to HCC), society may benefit by knowing this beforehand, thus allowing the liver to be given to another patient on the transplant list.
Discussion
Questions:
  1. What findings at MR examination (done for research purposes) does the researcher have an ethical obligation to share with the patient and/or the patient's hepatologist and surgeon prior to transplant?

  2. Does the researcher have a right to withhold potentially clinically relevant information until after the liver transplant?

  3. Does the patient have a right to request that such information be withheld from the hepatologist or surgeon?
Discussion
Summary: