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Case for Discussion Along with Drs. Hopkins and Carpender, you have submitted a co-authored paper reporting on the regulation of a gene introduced by transfection into fibroblasts. The paper is returned from the editor with two very positive reviews, suggesting only minor revisions. While the paper is being revised, one of Hopkins' postdocs presents data at an lab meeting demonstrating that the results of the gene regulation experiments are dependent on the concentration of DNA used to transfect the cells. She presents data showing that if the concentration of the gene construct is increased five fold, the previously reported regulatory effects are completely abolished. In light of these results, Hopkins argues that the paper should be withdrawn and not allowed to go to press. Carpender strongly objects to this. He argues that the results of the paper are reproducible and the interpretations of the results straightforward. He further argues that the new results may be the basis for a whole new paper, and that these data shouldn't even be mentioned in the paper. Carpender argues that the paper be published with the minor revisions suggested by the reviewers. used with permission |
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